DEPRESSION AND DEPRESSION ACCOMPANIED BY ANXIETY:

Adults:

The recommended starting dose is 150mg each day in divided doses after food or as a single dose at bedtime.

This may be increased up to 300mg each day in single or divided doses.

The major portion of a divided dose is to be taken at bedtime. If you are in hospital the dose may be further increased to 600mg each day in divided doses.

Elderly:

Dosage in elderly or frail patients should be started at 100mg each day in divided doses or as a single dose at bedtime. This may be increased by your doctor depending on how you react to this medicine. Dosages above 300mg each day are unlikely to be required.

Use in children and adolescents

Trazodone is not recommended for use in children and adolescents under 18 years of age.

ANXIETY:

The recommended starting dose is 75mg each day and this may be increased to 300mg each day as necessary.

If you take more trazodone tablets than you should

It is important to stick to the dose on the label of the medicine. Do not adjust your dose without consulting with your doctor.

If you or someone else swallows several of these tablets all together, contact your doctor or nearest hospital emergency department immediately. Always take any tablets left over with you along with the box, as this will allow easier identification of the tablets.

The following effects may occur: nausea, sickness, drowsiness, dizziness, fainting, fits (seizures), confusion and problems with your heart or breathing.

If you forget to take trazodone tablets

If you forget to take a dose, take it as soon as you remember. If it is almost time for your next dose do not take a double dose to make up for a forgotten dose, just carry on as before.

If you stop taking trazodone tablets

• Keep taking trazodone until your doctor tells you to stop. Do not stop taking trazodone just because you feel better
• When your doctor tells you to stop taking these tablets he/she will help you stop taking them gradually
• Stopping your medicine too quickly could cause sleep problems, leave you feeling more irritable than usual and cause you to sweat more than usual.

Stop taking trazodone and see a doctor or go to a hospital straight away if you experience:

• A long lasting and painful erection unrelated to sexual activity that will not go away (priapism)
• You get swelling of your face, lips, tongue, throat, hands or ankles, swallowing or breathing difficulties or itching of the skin and nettle rash. This is an allergic reaction to trazodone
• Yellowing of the eyes or skin which could be a liver problem (such as jaundice) or other abnormalities of liver function
• You have severe abdominal pain and bloating, which may be accompanied by vomiting or constipation. These may be signs that your intestine is not working properly (paralytic ileus)
• Bruising more easily than usual. This could be because of a blood disorder (thrombocytopenia)
• Getting more infections than usual (sore throat, skin infections) which may indicate a blood disorder (agranulocytosis).

Talk to your doctor straight away if you notice the following side-effects:

• Thoughts of harming or killing yourself
• Feeling tired, faint, dizzy, having pale skin. These could be signs of anemias
• Convulsions, fits (seizures)
• Unusual skin sensations such as numbness, tingling, pricking, burning or creeping on the skin (paresthesia)
• Feeling confused, restless, sweating, shaking, shivering, hallucinations (strange visions or sounds), sudden jerks of the muscles or a fast heartbeat, you may have something called Serotonin syndrome
• Feeling very unwell possibly with shortness of breath (dyspnea), difficulty in walking or walking with a shuffling gait, shaking, uncontrolled muscle twitching and a high temperature (above 38°C). This could be a rare condition known as Neuroleptic Malignant Syndrome
• Rapid, slow or irregular heartbeat.

Below is a list of other side effects that have been reported with the following frequency:

Not known (frequency cannot be estimated from the available data)

• Feeling drowsy or sleepy, tiredness
• Feeling less alert than usual
• Feeling sick (nausea) or being sick (vomiting), indigestion
• Constipation, diarrhoea
• Dry mouth, altered taste, increased amounts of saliva, blocked nose
• Sweating more than usual
• Dizziness, headache, confusion, weakness, tremor (shaking)
• Blurred vision
• Loss of appetite and weight loss
• Feeling dizzy or light-headed on standing or sitting up quickly (postural hypotension), fainting (syncope)
• Feeling restless and having difficulty sleeping
• Water retention which may cause swollen arms or legs
• Skin rash, itching
• Chest pain
• Pain in limbs, back pain, pain in your muscles, pain in your joints
• Jerking movements that you cannot control, mainly of the arms and legs, uncontrolled muscle movements or twitches
• Frequent infections with high temperature, severe chills, sore throat or mouth ulcers
  These could be signs of a blood problem called leucopenia
• Feeling anxious or more nervous than usual, feeling agitated
• Overactive behavior or thoughts (mania), believing things that are not true (delusions), memory disturbance
• Nightmares
• Decreased sex drive
• Feeling dizzy, possibly with a “spinning” feeling (vertigo)
• High blood pressure
• High temperature
• Flu type symptoms
• Difficulty with speaking
• Higher than normal number of white blood cells (seen by a blood test).
• High levels of liver enzymes in your blood (shown by a blood test).
• Severe liver disorders such as hepatitis.
• Liver failure with potential fatal outcome.
• Feeling tired, weak and confused, having muscle that ache, are stiff or do not work well. There may also be headache, loss of appetite, nausea or vomiting, convulsion. This may be due to low sodium levels in your blood.

BUY TRAZODONE TABLETS UK

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store

By reporting side effects you can help provide more information on the safety of this medicine.

How to Store

HOW TO STORE TRAZODONE TABLETS

• Keep this medicine out of the sight and reach of children.
• Do not store above 25°C. Store in the original packaging.
• Do not use this medicine after the expiry date which is stated on the blister and carton. The expiry date refers to the last day of that month.
• Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment.